Provide technical peer review for DMPK and safety in vitro and in vivo study designs. You’ll refine protocols to ensure we generate "gold standard," actionable data.
Act as the technical lead for our external research partners and CROs.
Synthesize chemical, pharmacological, and PK data into high-quality summary reports and preclinical dossiers.
Contribute technical expertise to help the team generate and evolve an appropriate Target Product Profile (TPP), ensuring discovery programmes are aligned to the long-term patient needs.
Support the Project Leader/Pharmacology team in reviewing AI-generated drug predictions using your DMPK and safety knowledge to identify the candidates most likely to succeed in the clinic.
Bridge the gap between preclinical, tech, clinical, and commercial teams, providing insights on safety liabilities, drug exposure, and population suitability.
Proactively seek opportunities to use AI and advanced computational tools to generate and refine DMPK and safety knowledge.

Experience in DMPK within biotech or pharma
Strong expertise in DMPK modelling (e.g. Phoenix WinNonlin or similar tools)
Ability to integrate diverse datasets into clear scientific narratives
Experience using Electronic Lab Notebooks (ELN) and preparing technical reports and preclinical dossiers
Strong literature and database mining skills, particularly for safety data
Experience
or strong interest
in interpreting non-clinical safety and toxicology data
Familiarity with evaluating toxicology packages and identifying dose-limiting toxicities
Experience in oncology and/or neurology is advantageous

Competitive salary, share options, 7% employer pension contributions, life insurance of 4x base salary
Private medical insurance
25 days annual leave (plus bank holidays) with the option to purchase additional days to support a healthy work-life balance and wellbeing support
Flexible and remote working options
Home office set-up allowance
Enhanced family leave policies and flexible working practices
Personal learning and development budgets
Regular personal development conversations and career support
Opportunities to engage with rare disease patient communities and gain insight into patient experiences.
One paid volunteering day per year to support a cause aligned with our mission

Healx

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