Senior Machine Learning Engineer – Omics, Graph Intelligence

Role Overview

• Build and deploy machine learning models over omics data (e.g. genomics, transcriptomics, proteomics, epigenomics, and multi-omics), capturing biological structure, variability, and experimental context.
• Work with major omics and biomedical databases (e.g. gene, protein, pathway, interaction, and expression resources) to integrate heterogeneous biological signals into unified learning pipelines.
• Develop and apply foundation models for biological data, including sequence-based, expression-based, and multi-modal models, adapting them to downstream scientific and product use cases.
• Design ML systems that populate, enrich, and reason over a biological knowledge graph, connecting entities such as genes, proteins, pathways, phenotypes, diseases, and experimental evidence.
• Apply graph-based methods tailored to biology, including graph embeddings, message passing, and network-aware learning, to model molecular interactions and biological systems.
• Collaborate with BenchSci’s Science team to ensure models reflect biological constraints, experimental design, and domain nuance, not just statistical patterns.
• Power downstream experiences by surfacing insights through semantic search, recommendation, and conversational AI / chat-based scientific assistants.
• Improve scalability, robustness, and interpretability of models operating on large, sparse, noisy, and biased omics datasets.
• Lead technical decision-making within the ML team, mentor other engineers, and help define best practices for applied ML in biomedical settings.
• Own projects end-to-end, from data exploration and model prototyping to production deployment and monitoring.
• Continuously improve the performance and scalability of ML models that are at the core of BenchSci’s products
• Regularly investigating what technologies will best enable BenchSci to effectively generate use cases
• Advocate for code and process improvements across yourteam, and help to define best practices based on personal industry experience and research
• Participate in sprint planning, estimation and reviews. Take ownership of deliverables, and work with teammates to ensure high-quality deliverables

Requirements

• Bachelor’s degree or higher in Computer Science, Mathematics, Machine Learning, Bioinformatics, or a related field.
• Leadership: 2+ years of tech lead experience in a production ML environment.
• Hands-on experience working with omics data and omics derived resources, such as genomic sequences, expression matrices, protein data, or biological networks.
• Familiarity with omics and biomedical databases (e.g. gene/protein annotations, interaction networks, pathway databases, expression atlases).
• Experience with or strong interest in biological foundation models, such as sequence models, embedding models, or multi-modal models applied to molecular or cellular data.
• Solid understanding of graph methods in a biological context, including knowledge graphs, molecular interaction networks, or pathway-level representations.
• Experience applying NLP or LLM-based techniques to scientific text or integrating text-based evidence with structured biological data.
• Strong experience with TensorFlow, PyTorch, and Omics processing libraries.
• Comfort working across disciplines, collaborating closely with scientists, engineers, and product teams.
• A team player who strives to see teammates succeed together.
• A growth mindset, strong ownership mentality, and desire to work on scientifically meaningful problems.
• You have a constant desire to grow and develop.

Tech Stack

• PyTorch
• Tensorflow

Benefits

• A great compensation package that includes BenchSci equity options
• A robust  vacation policy plus an additional vacation day every year
• Company closures for 14 more days throughout the year
• Flex time for sick days, personal days, and religious holidays
• Comprehensive health and dental benefits
• Annual learning & development budget
• A one-time home office set-up budget to use upon joining BenchSci
• An annual lifestyle spending account allowance
• Generous parental leave benefits with a top-up plan or paid time off options
• The ability to save for your retirement coupled with a company match!