Serve as the final scientific authority for complex or ambiguous variant interpretation cases, including conflicting clinical and functional evidence
Apply deep expertise in ACMG/AMP guidelines to ensure accurate and defensible classifications
Leverage clinical experience to contextualize variant interpretations and ensure clinical relevance and applicability
Guide evaluation of functional studies and literature to support high-confidence interpretation decisions
Support high-impact client deliverables, including clinical and pharmaceutical use cases
Own QA/QC standards across all variant interpretation workflows
Ensure consistent application of internal frameworks, nomenclature standards (HGVS), and interpretation criteria
Oversee external data quality, including ClinVar submissions and discrepancy resolution
Manage, mentor, and develop a team of QA scientists and curators
Provide coaching on interpretation, evidence evaluation, and best practices
Set clear performance expectations and maintain accountability for quality standards
Design, implement, and continuously improve SOPs, QA processes, and workflows
Identify systemic quality issues and lead solutions that scale across teams and projects
Balance standardization with flexibility to meet diverse client and product needs
Partner with product, engineering, and leadership to improve tools, workflows, and data quality
Contribute to broader data and product strategy through scientific expertise

5+ years of hands-on variant interpretation experience in a clinical or equivalent setting
Advanced degree (PhD, MS in Genetics/Genomics) or Genetic Counselor (CGC)
Deep expertise applying ACMG/AMP guidelines in complex scenarios
Strong experience evaluating clinical and functional evidence from scientific literature
Proficiency in HGVS nomenclature, including normalization and variant disambiguation
Demonstrated ability to make independent, high-confidence scientific decisions.

Manager, Genetic Quality Assurance, Product Quality – Variant Interpretation, Genomics

Key skills