Develop and deploy ML/AI models to support safety signal detection, dose selection, PK/PD modeling, toxicology insights, and translational interpretation.
Implement representation‑learning, predictive modeling, and multivariate analytics for datasets spanning in vivo studies, in vitro assays, exposure‑response data, and pathology information.
Partner with scientific SMEs to design modeling strategies aligned with PSTS decision points.
Apply model governance, versioning, and validation standards consistent with R&D AI practices.
Build and maintain scalable data pipelines that integrate PSTS‑relevant data sources (e.g., toxicology studies, PK/PD datasets, biomarker readouts, animal study repositories).
Transform raw experimental outputs into standardized, analysis‑ready, AI‑ready datasets using Python, R, and cloud‑native services.
Work directly with toxicology, DMPK, and safety stakeholders to interpret scientific context and translate study designs into computational requirements.
Collaborate with PSTS functional experts, R&D Data Science teams, and platform architects to ensure high-quality, scalable data solutions.

Advanced degree (MS or PhD) in Data Science, Computational Biology, Toxicology, Pharmacology, Biomedical Engineering, Computer Science, or related field.
3+ years of experience applying machine learning and/or data engineering to scientific or biomedical datasets.
Proficiency with Python and/or R, SQL, and modern data engineering tooling (cloud computing, workflow orchestration, version control).
Experience with ML model development, evaluation, and deployment pipelines.
Experience working with biological, toxicology, PK/PD, or in vivo datasets.

Vacation –120 hours per calendar year
Sick time
40 hours per calendar year; for employees who reside in the State of Colorado –48 hours per calendar year; for employees who reside in the State of Washington –56 hours per calendar year
Holiday pay, including Floating Holidays –13 days per calendar year
Work, Personal and Family Time
up to 40 hours per calendar year
Parental Leave – 480 hours within one year of the birth/adoption/foster care of a child
Bereavement Leave – 240 hours for an immediate family member: 40 hours for an extended family member per calendar year
Caregiver Leave – 80 hours in a 52-week rolling period
Volunteer Leave – 32 hours per calendar year
Military Spouse Time-Off – 80 hours per calendar year

Principal Data Scientist – R&D DSDH, Preclinical Sciences, Translational Safety

Key skills