Own key assays and workflows for CAR design, T-cell engineering, and in vitro functional characterization
Partner with project teams to enable data-driven decisions that advance programs from discovery toward translation
Help shape study plans, and ensure timely delivery of milestones across functions
Design and run in vitro studies for CAR T candidates; design constructs and characterize engineered cell therapies; develop, execute, and optimize functional assays
Analyze data, generate figures, and prepare reports and slide decks, present results and propose next experiment steps
Ensure adherence to required training and maintain accurate, complete experimental records
Align with Pharmacology & Toxicology, CMC, translational science and clinical teams to advance project
Clear scientific writing and presentation, mentor colleagues and foster a productive, well-organized lab environment
Track record of trouble shooting models, optimizing protocols, and meeting timelines in a dynamic environment

PhD in immunology, cell biology, or related field; or MS with 4+ years demonstrated impact in cell therapy discovery
Proficient in human primary cell isolation, culture, activation, and maintenance
Prepare lentiviral vectors and perform transduction; optimize MOI to maximize transduction efficiency; assess vector copy number and integration characteristics; conduct electroporation-based gene edits
Proficient in panel design, compensation, and gating
Functional assays: target killing (luciferase/impedance), cytokines, proliferation/persistence, serial-kill or rechallenge assays; antigen density titration and specificity testing
PCR/qPCR, plasmid prep; amplicon NGS prep for edit verification and transgene integrity
Proficiency with ELN, FlowJo, Snapgene, GraphPad; understanding of assay acceptance criteria and basic statistics
Practice BSL 2 biosafety, uphold animal ethics (IACUC), maintain awareness of research GxP, and ensure data integrity

Scientist, Cell Therapy

About this role