Lead Product Manager, Clinical Genomics

Natera is a global leader in cell-free DNA testing, dedicated to oncology, women’s health, and organ health. They are seeking a Lead Product Manager to define and drive strategy for core components of the Results, Interpretation, and Reporting platform, ensuring scalable and compliant clinical software systems.

Responsibilities:

• Define and drive multi-year product strategy and roadmap across one or more RIR components, ensuring alignment to clinical quality, regulatory requirements, and commercial scale objectives
• Influence platform-level technical direction in partnership with engineering leadership
• Partner closely with software engineering, bioinformatics, clinical domain experts, quality, regulatory, and other product teams
• Translate business, clinical, and operational needs into clear, actionable product requirements
• Define and evolve end-to-end user workflows, including UI/UX requirements and supporting backend functionality
• Drive cross-team alignment on shared data contracts and workflow standards
• Mentor and raise the bar for product management within the RIR organization
• Own measurable improvements in clinical workflow efficiency, reliability, and operational scalability
• Establish prioritization frameworks that balance regulatory risk, clinical impact, technical scalability, and business outcomes across RIR investments
• Develop and track quantitative metrics related to usability, performance, reliability, and adoption
• Lead delivery teams with clear strategic direction, ensuring requirements reflect long-term platform goals, validation readiness, and system interoperability
• Proactively identify systemic risks, architectural constraints, and workflow inefficiencies that may limit scale or regulatory robustness, and lead cross-functional initiatives to resolve them
• Partner with Quality and Regulatory leadership to shape validation strategy, risk classification, traceability, and audit readiness for RIR software systems
• Create clear, data-driven written proposals and presentations to support stakeholder alignment and decision-making
• Act as a subject matter expert for owned components, supporting design, testing, validation, rollout, and ongoing use

Requirements:

• Bachelor's degree in life sciences, engineering, computer science, statistics, or equivalent experience
• 7+ years of experience in software product management, including ownership of complex, multi-team or platform-level initiatives
• 5+ years experience working on production software in healthcare, clinical genomics, or other regulated lifesciences domains, with demonstrated impact on validation, compliance, and system scalability
• Demonstrated experience influencing engineering architecture and long-term technical investment decisions
• Proven ability to drive alignment across highly matrixed organizations without direct authority
• Track record of independently operating in ambiguous environments and establishing product direction
• Experience with clinical genomics and variant processing and interpretation workflows
• Experience owning user-facing applications, tools, or operational software
• Familiarity working with backend services, APIs, or data-driven systems
• Familiarity with Next Generation Sequencing concepts is beneficial