Software Engineer - .NET Full Stack Developer

Mayo Clinic is a top-ranked healthcare provider dedicated to patient care and employee support. They are seeking a Software Engineer to design, develop, and maintain .NET-based back-end services for genomics and clinical applications, ensuring performance and reliability while collaborating with cross-functional teams.

Responsibilities:

• Design, develop, and maintain robust .NET-based back-end services supporting a broad portfolio of genomics and clinical applications
• Build and optimize services that handle complex genomic workflows, large-scale clinical datasets, and high-throughput data processing
• Ensure that all services meet strict performance, reliability, and accuracy requirements, scale effectively as data volumes grow, and remain resilient within hybrid cloud ecosystems
• Collaborate closely with Product Owners, Product Managers, Architects, and cross-functional engineering partners to translate requirements into well-architected, maintainable code
• Design and implement services aligned to enterprise architecture, including cloud-ready APIs, data integration pipelines, and secure interoperability layers for genomic systems
• Participate in Agile and DevOps practices using GitHub, Azure DevOps (ADO), Azure Pipelines, and CI/CD frameworks
• Work may include deployment automation and configuration management using tools such as ARM/Bicep, Terraform, Cloud Build, or Azure Pipelines, supporting both on-prem and cloud-hosted applications
• Maintain comprehensive technical documentation, contribute to code reviews, and participate in expert-level troubleshooting through log analysis, root cause evaluation, and data/system investigation
• Communicate effectively with peers, leaders, and clinical partners across the organization
• Build knowledge of genomics workflows, organizational processes, and customer needs while performing a range of technical assignments with moderate guidance and increasing autonomy

Requirements:

• Bachelor's degree in computer science/engineering or related field; Or an associate's degree in computer science/engineering or related field with an additional 2 years of experience as described below
• Have working knowledge and experience of Software Engineering with a minimum of internships and a minimum of 1 year of experience, or 2 years of experience coding applications or services in a high-level language (C, C++, Golang, Java, C# etc.)
• Demonstrated problem solving and time management skills
• Possesses strong technical aptitude for designing and implementing software solutions
• Experience with modern application development frameworks
• Knowledge of professional software engineering practices & best practices for the full software development life cycle, including coding standards, code reviews, source control management, build processes, testing, and operations
• Deep hands-on technical expertise, excellent verbal and written communication skills
• Experience with Agile software development techniques
• Experience developing applications in hybrid environments, including on-premises systems, Azure, and Google Cloud Platform (GCP)
• Familiarity with building and integrating RESTful APIs, microservices, and web services using .NET technologies
• Knowledge of DevOps pipelines and CI/CD using Azure DevOps, GitHub Actions, or Azure Pipelines
• Utilization of AI coding tool such as GitHub CoPilot, Gemini, Claude
• Experience with relational and NoSQL databases, analytics platforms, big-data processing, or enterprise data pipelines
• Background in developing high-performance, scalable, and highly available distributed systems
• Experience supporting or developing solutions in healthcare, clinical, Bioinformatics or genomics-focused applications is highly desirable
• Ability to use a wide variety of open-source technologies and cloud-based services
• Experience with Google and Azure cloud environments
• Experience in databases, analytics, big data systems or business intelligence products
• Experience with building high-performance, highly available and scalable distributed systems
• Experience developing software for healthcare related industries