Manager, Quality Assurance and Product Quality (Variant Interpretation)

Genomenon is an AI-driven biomedical intelligence company dedicated to improving lives through actionable biomedical information. They are seeking a Manager, Quality Assurance and Product Quality (Variant Interpretation) to lead variant interpretation efforts, ensuring data accuracy and supporting clinical decision-making. This role involves managing a team, driving quality standards, and collaborating across functions to enhance processes and outcomes.

Responsibilities:

• Serve as the final scientific authority for complex or ambiguous variant interpretation cases, including conflicting clinical and functional evidence
• Apply deep expertise in ACMG/AMP guidelines to ensure accurate and defensible classifications
• Leverage clinical experience to contextualize variant interpretations and ensure clinical relevance and applicability
• Guide evaluation of functional studies and literature to support high-confidence interpretation decisions
• Support high-impact client deliverables, including clinical and pharmaceutical use cases
• Own QA/QC standards across all variant interpretation workflows
• Ensure consistent application of internal frameworks, nomenclature standards (HGVS), and interpretation criteria
• Oversee external data quality, including ClinVar submissions and discrepancy resolution
• Manage, mentor, and develop a team of QA scientists and curators
• Provide coaching on interpretation, evidence evaluation, and best practices
• Set clear performance expectations and maintain accountability for quality standards
• Design, implement, and continuously improve SOPs, QA processes, and workflows
• Identify systemic quality issues and lead solutions that scale across teams and projects
• Balance standardization with flexibility to meet diverse client and product needs
• Partner with product, engineering, and leadership to improve tools, workflows, and data quality
• Contribute to broader data and product strategy through scientific expertise

Requirements:

• 5+ years of hands-on variant interpretation experience in a clinical or equivalent setting
• Advanced degree (PhD, MS in Genetics/Genomics) or Genetic Counselor (CGC)
• Deep expertise applying ACMG/AMP guidelines in complex scenarios
• Strong experience evaluating clinical and functional evidence from scientific literature
• Proficiency in HGVS nomenclature, including normalization and variant disambiguation
• Demonstrated ability to make independent, high-confidence scientific decisions
• Experience with ClinVar submissions and resolving interpretation discrepancies
• Prior people management or strong leadership experience
• Experience developing SOPs
• Exposure to a broad range of disease areas or gene classes