Staff, Software Engineer

Tempus AI is seeking a Staff Software Engineer to help lead the design and development of their Java/Spring and React platform for precision genomics and clinical reporting products. This role involves technical leadership, setting direction across services, and collaborating with domain experts to ensure reliable and performant systems in a regulated environment.

Responsibilities:

• Architect, develop, and enhance Java/Spring and React applications supporting scientific workflows for variant identification, curation, ranking, and clinical reporting
• Design and own data models, APIs, and search/query strategies that make large-scale genomic variant data fast and precise to filter, faceted, and retrieve at scale
• Partner directly with scientific and clinical subject matter experts to translate complex domain requirements into clear, well-scoped technical designs
• Lead design and development of scalable, maintainable, and secure solutions, and drive alignment on technical direction across teams through design docs and architecture reviews
• Troubleshoot complex production issues across the stack, resolve root causes, and measurably improve system reliability, observability, and performance
• Use AI-assisted development tools effectively and responsibly to accelerate delivery, and help the team establish good practices for their use
• Advocate for best practices in software engineering, code quality, automated testing, and CI/CD
• Other duties as assigned

Requirements:

• Bachelor's degree in computer science, Information Technology, or a related field or equivalent work experience
• 8+ years of experience in software engineering, with a focus on full-stack application development
• Proven leadership experience, with the ability to lead by example and mentor engineers
• Strong expertise in cloud-based solutions and experience integrating third-party software into existing systems
• Extensive experience in building service-oriented architectures and designing RESTful API services to support scalable and maintainable applications
• Excellent problem-solving skills with the ability to troubleshoot and resolve technical challenges efficiently
• Effective communication skills, capable of articulating complex technical concepts to non-technical stakeholders
• Experience with search and query technologies such as OpenSearch or Elasticsearch, including index and mapping design, query performance tuning, and faceted filtering over large datasets
• Experience and familiarity working in Java / Spring, React
• Experience working with relational databases (PostgreSQL, MySQL) and NoSQL technologies (OpenSearch/Elasticsearch, MongoDB, DynamoDB)
• Master's degree
• Experience in scientific, genomics, or healthcare-related applications is a plus
• Experience designing, developing, and deploying cloud-native applications on public cloud platforms such as AWS, Azure, or GCP