Staff, Software Engineer

Tempus AI is seeking a Staff Software Engineer to lead the design and development of Java/Spring and React platforms supporting precision genomics and clinical reporting products. The role provides hands-on technical leadership across services, partners with scientific and clinical experts, and drives reliable, performant, secure systems in a regulated clinical environment.

Responsibilities:

• Architect, develop, and enhance Java/Spring and React applications supporting scientific workflows for variant identification, curation, ranking, and clinical reporting
• Design and own data models, APIs, and search/query strategies that make large-scale genomic variant data fast and precise to filter, faceted, and retrieve at scale
• Partner directly with scientific and clinical subject matter experts to translate complex domain requirements into clear, well-scoped technical designs
• Lead design and development of scalable, maintainable, and secure solutions, and drive alignment on technical direction across teams through design docs and architecture reviews
• Troubleshoot complex production issues across the stack, resolve root causes, and measurably improve system reliability, observability, and performance
• Use AI-assisted development tools effectively and responsibly to accelerate delivery, and help the team establish good practices for their use
• Advocate for best practices in software engineering, code quality, automated testing, and CI/CD
• Other duties as assigned

Requirements:

• Bachelor's degree in computer science, Information Technology, or a related field or equivalent work experience
• 8+ years of experience in software engineering, with a focus on full-stack application development
• Proven leadership experience, with the ability to lead by example and mentor engineers
• Strong expertise in cloud-based solutions and experience integrating third-party software into existing systems
• Extensive experience in building service-oriented architectures and designing RESTful API services to support scalable and maintainable applications
• Excellent problem-solving skills with the ability to troubleshoot and resolve technical challenges efficiently
• Effective communication skills, capable of articulating complex technical concepts to non-technical stakeholders
• Experience with search and query technologies such as OpenSearch or Elasticsearch, including index and mapping design, query performance tuning, and faceted filtering over large datasets
• Experience and familiarity working in Java / Spring, React
• Experience working with relational databases (PostgreSQL, MySQL) and NoSQL technologies (OpenSearch/Elasticsearch, MongoDB, DynamoDB
• Master's degree
• Experience in scientific, genomics, or healthcare-related applications is a plus
• Experience designing, developing, and deploying cloud-native applications on public cloud platforms such as AWS, Azure, or GCP