Clinical Project Manager

Curavit Clinical Research is seeking a full-time Clinical Project Manager to lead clinical research project delivery from study startup through close-out. The role owns client relationships, contracts, project financials, cross-functional coordination, risk and change management, stakeholder communications, and clinical trial systems implementation.

Responsibilities:

• Serve as the point of contact for client services, owning the relationship from contract award through study close-out
• Build and maintain trusted, long-term client relationships. Understand client priorities and represent them internally while protecting company interests
• Lead regular client governance meetings, status reporting, and escalation discussions
• Manage difficult conversations with the client, including scope disputes, delays, and requests that fall outside the contract, with professionalism and transparency
• Monitor client satisfaction and proactively address concerns before they escalate
• Identify opportunities for additional scope or future work and partner with Solutions where appropriate
• Own the study contract, including the MSA, work orders, and budget. Ensure that all delivered work aligns with contracted scope and terms
• Identify out-of-scope requests. Initiate, negotiate, and execute change orders in a timely manner
• Own project financials, including budget tracking, revenue recognition inputs, forecasting, and margin management
• Review and approve invoices, pass-through costs, and vendor spend. Ensure accurate and timely client billing against milestones
• Report on project financial health to leadership, flagging budget variances, risks to margin, and recovery plans
• Partner with Solutions, Finance and Legal on contract amendments, payment issues, and financial close-out
• Manage the simultaneous implementation of multiple, parallel clinical trial builds using formal project planning techniques
• Define project scope, deliverables, and milestones in support of study objectives and contracted terms
• Hold overall accountability for study delivery, overseeing study design, schedule, and budget
• Partner closely with the Clinical Trial Manager (CTM), who leads day-to-day clinical operations execution. Align on priorities, timelines, resourcing, and issue resolution
• Set and continuously manage client and stakeholder expectations, incorporating operational updates and input from the CTM
• Communicate and collaborate with operational, clinical, and technical stakeholders to assess study design and technology, ensuring that study requirements and regulatory expectations are met
• Collaborate with the CTM, other departments, and vendors to ensure resources supporting the study are allocated on time and within budget
• Facilitate clinical trial systems design, review, and testing sessions with internal and external partners
• Lead learning reviews and drive post-launch performance reviews
• Oversee study close-out in partnership with the CTM. The CPM owns final client reporting, contract close-out, and financial reconciliation, and the CTM leads operational close-out activities
• Assess and manage the impact of risks, issues, and change requests on study design, schedule, budget, and contract
• Develop mitigation recommendations and escalate to Senior Leaders and/or the Steering Committee when appropriate
• Maintain clinical trial systems and documentation, and manage change requests through to formal change orders where scope or budget is affected
• Identify and resolve issues and conflicts within the study team
• Identify and manage study dependencies and critical paths
• Develop and maintain ongoing communications with internal and external stakeholders
• Act as the single voice to the client. Coordinate input from functional leads so the client receives consistent, aligned communication
• Communicate and collaborate with the CTM, clinical operations, and training stakeholders to ensure technical solutions and operational processes are well documented and understood
• Provide oversight of study documentation and operational assets (OPAs), partnering with the CTM to ensure they are developed, maintained, and inspection-ready in the TMF and/or ISF
• Own the maintenance of project management, contractual, and financial documentation, including the project plan, change orders, and budget records

Requirements:

• Bachelor's degree in life sciences, healthcare, business, project management, or a related field. An equivalent combination of education and relevant experience may be considered
• Minimum of five years of clinical research or clinical trial operations experience, including responsibility for managing cross-functional study activities
• Demonstrated understanding of the end-to-end clinical trial lifecycle, including start-up, conduct, data management, and close-out
• Proven experience serving as the single point of contact for Sponsors or clients, with ownership of the overall client relationship from contract award through close-out
• Demonstrated ability to build trusted client relationships while protecting company interests, including managing escalations, scope disputes, and out-of-scope requests
• Experience owning study contracts, including MSAs, work orders, and statements of work, and ensuring delivery aligns with contracted scope and terms
• Experience identifying out-of-scope work and initiating, negotiating, and executing change orders
• Experience owning project financials, including budgets, forecasts, invoicing, pass-through costs, vendor spend, and margin management
• Experience managing study timelines, vendors, and resources across multiple concurrent studies
• Experience working with globally distributed Sponsors, study teams, sites, and vendors
• Strong working knowledge of ICH-GCP and applicable local and international clinical research requirements
• Ability to lead cross-functional teams and influence stakeholders without direct reporting authority, coordinating functional input so the client receives consistent, aligned communication
• Strong commercial acumen, with the ability to recognize opportunities for additional scope and partner with Business Development, Solutions, and Senior Leadership where appropriate
• Strong financial-management, organizational, analytical, negotiation, decision-making, and problem-solving skills
• Excellent written and verbal communication skills, including confidence leading client governance meetings and difficult conversations
• Professional fluency in written and spoken English is required
• Proficiency with project-management tools, clinical trial systems, and collaboration platforms
• Experience coordinating decentralized, hybrid, virtual, and/or traditional site-based studies is preferred
• Knowledge of European clinical research and data-privacy requirements is preferred
• Proficiency in an additional language is an advantage
• Project Management Professional (PMP) certification or another recognized project-management qualification is preferred