Staff Software Development Engineer (Lab Technology) #4907

GRAIL is a healthcare company pioneering technologies for early cancer detection through next-generation sequencing, clinical studies, and computer science. The Staff Software Development Engineer will design, build, and operate reliable software systems for automated laboratories, including workflow orchestration, LIMS, quality decision systems, and laboratory visibility tools. The role provides technical leadership across distributed systems, laboratory automation, regulatory compliance, and clinical operations.

Responsibilities:

• As a Staff Software Engineer, you'll design, build, and operate the software systems that power GRAIL's automated laboratories
• You'll work across services including laboratory workflow orchestration, LIMS, quality decision systems, and laboratory visibility tools that enable operators to safely process patient samples at scale
• The challenges you'll solve extend well beyond traditional backend software development. You'll collaborate closely with laboratory operators, scientists, automation engineers, and software engineers to understand complex laboratory workflows and build systems that remain reliable under real-world operating conditions
• This work requires balancing reliability, scalability, regulatory compliance, and operational simplicity. You'll design software that recovers gracefully from failures, supports 24-hour laboratory operations, improves operator efficiency, and enables the laboratory to continue evolving as new assays and technologies are introduced
• You'll help build resilient distributed systems that interact with physical laboratory equipment, support software-only disaster recovery, and continuously improve the intelligence and efficiency of the laboratory platform
• Most importantly, every improvement you make helps GRAIL process patient samples more reliably, efficiently, and at greater scale
• Senior engineers lead the design and delivery of significant technical initiatives, mentor teammates, and own critical production systems
• Staff engineers provide technical leadership across multiple systems and teams, shape architectural direction, lead large multi-quarter initiatives, raise engineering standards, and influence how GRAIL's laboratory platform evolves to meet future scientific and operational needs

Requirements:

• Strong software engineering fundamentals with experience designing and operating distributed systems
• Experience building production software using one or more modern programming languages such as Python or Go
• Experience with modern frontend development using React and TypeScript
• Experience developing cloud-native applications on AWS
• Experience building APIs and distributed services using technologies such as REST and/or gRPC
• Experience with Kubernetes and cloud-native deployment practices
• Strong understanding of software quality, testing, observability, and operational ownership
• Excellent communication skills and the ability to collaborate across engineering, science, and laboratory operations
• Experience with observability tooling (Prometheus/Grafana, structured logging) and on-call ownership