ML Research Scientist

Topos Bio is developing computational methods to drug intrinsically disordered proteins. The ML Research Scientist will develop and optimize machine learning methods spanning simulation, protein modeling, and small molecule design, while collaborating with computational and experimental scientists to validate models against biophysical data.

Responsibilities:

• Develop generative models for protein conformational ensembles trained on simulation and experimental data
• Build novel ML architectures for ensemble-based affinity prediction and generative chemistry
• Adapt methods from research literature to disordered protein targets
• Design scalable training pipelines for high-throughput experimentation
• Collaborate with computational and experimental scientists to validate models against biophysical data