Description
A little about us:
The Lieber Institute for Brain Development (LIBD) was established in 2010 to plot a new course in biomedical research that would change the lives of individuals affected with developmental brain disorders. We are one of the only research institutions in the world focused specifically on understanding how genes and the environment influence the way our brains develop that lead to conditions such as schizophrenia, autism, bipolar disorder and related developmental brain disorders. Through our cutting-edge research, answers are emerging and being translated into a robust pipeline of new drugs in development. And, by focusing on genes and their dynamic interplay with the environment, we are getting even closer to the “holy grail” in medical research, the discovery of strategies for primary prevention.
We are a group of dedicated, multidisciplinary and optimistic researchers, working at the cutting edge of science, utilizing state-of-the-art tools to unlock the mystery of the brain and transform the way we approach the development of new treatments, and ultimately cures. LIBD is an independent 501(c)(3) medical research institute located in the Bioscience Park on the campus of the Johns Hopkins School of Medicine and Hospital in Baltimore, MD.
Job Summary:
A Staff Scientist position in computational biology and bioinformatics is available to work within the Neural Plasticity division at the Lieber Institute for Brain Development (LIBD). Our research investigates the molecular organization, development, and function of brain circuits involved in psychiatric disorders. We combine molecular profiling of postmortem human brain tissue with experimental mouse studies and human induced pluripotent stem cell (iPSC) and organoid models to understand how distinct neuronal populations contribute to brain function and disease, with the goal of discovering novel therapeutic targets.
The successful candidate will lead analyses of single-nucleus RNA sequencing, spatial transcriptomics, and other multiomic datasets generated by our team and collaborators. This position offers opportunities to develop computational approaches, shape research questions, and work closely with experimental scientists to connect molecular findings with cellular organization, circuit function, and behavior.
Specific Duties and Responsibilities:
· Analyze and interpret large-scale genomic and multiomic datasets from human brain tissue, mouse and organoid models, and public resources.
· Develop and apply computational and statistical approaches to address research questions in neuroscience and psychiatric disorders.
· Develop and maintain reproducible analysis workflows, with responsibility for data quality, documentation, and organization.
· Prepare scientific figures, write and revise manuscripts, and contribute to grant applications in collaboration with research teams.
· Present research findings at team meetings and scientific conferences.
· Other duties as assigned.
Required Minimum Qualifications:
· Master’s Degree or higher (PhD Preferred) in Computational Biology, Bioinformatics, Biostatistics, Genetics, Neuroscience, or related field is required.
· A minimum of 2 years related experience.
Special Knowledge, Skills, and Abilities:
· Proficiency in Linux and programming with R or Python
· Demonstrated experience analyzing large-scale transcriptomic or other genomic datasets, particularly single-nucleus and spatial transcriptomics data.
· Strong understanding of statistical analysis, including experimental design, regression or mixed-effects models, multiple testing, and sources of technical and biological variation.
· Familiarity with high-performance computing, version control, and reproducible analysis practices.
· Ability to independently develop analytical strategies, troubleshoot computational problems, and critically evaluate results.
· Expertise to ask and interpret biological questions underlying the data and ability to communicate findings clearly to colleagues with varied computational and experimental backgrounds is highly desired.
· Previous experience working on genomics datasets related to neuroscience or psychiatry is preferred but not required.
Physical Requirements:
· Incumbent is required to work in an office environment.
· Must be able to move about the office and campus as well as remain stationary for extended periods of time.
· Ability to continuously operate a personal computer for extended periods of time.
· Visual acuity as well as mental acuity sufficient to collect and interpret data, evaluate, reason, define problems, establish facts, draw valid conclusions, make valid judgments and decisions are required
· Ability to speak and hear well enough to communicate clearly and understandably with sufficient volume to ensure an accurate exchange of information in normal conversational distance, over the telephone, and in a group setting
· Physical dexterity sufficient to use hands, arms, and shoulders repetitively to operate a keyboard and other office equipment, use a telephone, access file cabinets and other items stored at various levels, including overhead
· Ability to lift or move objects up to 25 lbs.
** If accommodations are needed due to pregnancy or a disability, please contact jobs@libd.org
Compensation
Candidates are hired within the starting salary range for the position which is the lower portion of the overall range. The starting salary range for this position is $82k - $87k with opportunities for employee growth over time. Placement in the starting range is based on job-related skills and experience, as evaluated throughout the interview process.
Benefits
The Lieber Institute for Brain Development offers a competitive, comprehensive benefits package to help us attract and retain the best talent. Please visit https://www.libd.org/careers/benefits/ for more information.
EEOC Statement: At the Lieber Institute, we are committed to a work environment of mutual respect where employment decisions are based on merit. As an equal opportunity employer, the Lieber Institute does not discriminate in employment opportunities on the basis of race, color, religion, color, sex, gender identity/expression, sexual orientation, pregnancy, marital status, age, national origin or ancestry, citizenship, disability (physical or mental), genetic information, military service, or other non-merit based factors protected by state or federal law or local ordinance, with regard to any position or employment for which the applicant or employee is qualified.
LIEBER INSTITUTE FOR BRAIN DEVELOPMENT'S COMMITMENT TO DIVERSITY, EQUITY, AND INCLUSION
The Lieber Institute for Brain Development is a transparent and collaborative community working to produce unique and imaginative patient-oriented solutions to developmental neuropsychiatric disorders. It is committed to integrating scientists from diverse disciplines, cultures, and countries into a research team that draws upon the best of its staff. The Institute is historic—it is defining a unique model for ground-breaking science. It values translational science that revolutionizes the field and improves the quality of life for those affected by mental illness. The Institute provides an environment that fosters independent growth through mentorship and a supportive, collegial community. Diverse minds, ideas, and talent are needed to support LIBD's mission. Fresh, innovative ideas and perspectives are a competitive necessity in an increasingly diverse and global marketplace. The success of the Institute's mission depends upon leveraging a diversity of talent.
The Institute's commitment to diversity goes beyond compliance with laws and regulations that promote equal employment opportunity, prohibit discrimination and harassment, and support minority and woman owned businesses. To realize the advantages of its diversity, it is necessary to work effectively together even when differences challenge us to consider ideas and methods that seem impractical or make us feel uncomfortable.
The Lieber Institute for Brain Development demonstrates its commitment to diversity by:
·Including others: Talent is not limited to those with a narrow set of industry and academic credentials. The Institute is committed to building diverse teams, inviting others to share their perspectives, seeking out a diversity of input when making decisions, questioning traditional thinking, and promoting continuous learning and development.
·Respecting one another: The Institute is committed to listening carefully to others, seeking consensus, engaging in active and constructive debate, thoughtfully challenging one another, and providing constructive feedback.
·Building trust: The Institute is committed to sharing information and resources, depending on one another to get things done, keeping promises, and conveying high integrity in all actions.
