Executive Medical Director, Clinical Leader – Neuroscience, Early Development, Experimental Medicine

Role Overview

• Develop and lead clinical development strategies from IND/CTA through Phase I and Phase IIa Proof‑of‑Concept/Proof-of-Mechanism.
• Integrate translational hypotheses, biomarker strategies, precision measures (for patient selection, pharmacodynamic measures) and patient‑centric approaches into clinical plans.
• Ensure scientific rigor, clinical feasibility, and regulatory alignment in all development strategies.
• Lead the design of innovative and lean signal seeking early-phase clinical trials, including adaptive and biomarker‑enriched designs.
• Provide clinical oversight for study execution, including safety monitoring, dose selection, protocol amendments, and data interpretation.
• Leads cross-functional clinical study teams and work closely with biomarker, PK/PD, biostatistics, and operations teams to ensure high‑quality clinical execution.
• Be a core member of the early development compound team for specific assets.
• Guide decision‑making at project milestones and participate in governance reviews.
• Engage with regulatory affairs to inform early interactions with FDA, EMA, and other agencies.
• Establish and maintain relationships with global key opinion leaders, academic partners, and clinical investigators.
• Represent the company at scientific meetings, advisory boards, and consortiums in neuroscience and neurodegeneration.
• Contributes to in-licensing evaluations and due-diligence activities.
• Provide scientific and strategic leadership to clinical scientists and clinical development team members.
• Mentor or manage junior clinicians or scientists within Early Development and Experimental Medicine.
• Promote a culture of scientific excellence, patient focus, and collaborative innovation.

Requirements

• Minimum 5 years of clinical research experience in the biopharmaceutical industry, academia, or equivalent setting.
• Demonstrated experience leading early‑phase clinical trials; experience in PD, AD is highly desirable.
• Proven track record of advancing programs through early development milestones.
• Deep understanding of neurodegenerative diseases, including Alzheimer’s and Parkinson’s biology, clinical endpoints, and emerging modalities.
• Strong knowledge of translational neuroscience, biomarkers, and experimental medicine approaches.
• Experience with innovative trial designs, digital health tools, or fluid/imaging biomarkers is a plus.
• Strategic thinker with the ability to influence and drive cross‑functional teams.
• Outstanding communication and presentation skills, with the ability to engage senior leadership, and ensures alignment between various teams and stakeholders.
• Demonstrated ability to work in an agile, innovation‑driven environment.

Benefits

• medical, dental, vision, life insurance, short
• and long-term disability, business accident insurance, and group legal insurance
• participation in Company’s consolidated retirement plan (pension) and savings plan (401(k))
• participation in Company’s long-term incentive program
• Vacation – up to 120 hours per calendar year
• Sick time
• up to 40 hours per calendar year; for employees who reside in the State of Washington – up to 56 hours per calendar year
• Holiday pay, including Floating Holidays – up to 13 days per calendar year
• Work, Personal and Family Time
• up to 40 hours per calendar year