Principal Scientist – Medicinal Chemistry

Role Overview

• Lead drug discovery projects from hit validation to development candidate selection using all modern medicinal chemistry techniques to deliver low dose and safe oral therapies.
• Work collaboratively to strategize with corresponding functional area teams.
• Set the chemistry strategy for projects and advance drug discovery programs by collaboratively interacting cross-functionally.
• Communicate project plans/priorities to management and governance.
• Lead the preparation of patents, reports, and scientific publications.
• Manage global CROs and external partners on a day-to-day basis to achieve project goals.
• Has accountability for CROs timelines and data quality.
• Has accountability and is a contributor to SM inventorship.
• Serve as functional area expert in due diligence teams and early discovery partnerships & collaborations.
• Effectively communicates and collaborates across global sites and sets project strategy by providing leadership of cross-functional project teams.
• Represents the organization through external communication of impactful scientific research in the form of presentation at external conferences and publication in scientific journals and patents.
• Proposes and oversees external collaborations.
• Leader in the field of synthetic chemistry and small molecule drug design including but not limited to structure-based drug design (SBDD), phenotypic approaches, covalent modifiers, molecular glues, etc.
• Leads global, cross-functional experimental teams to achieve project goals and compound target profiles (PTP).
• Provides significant mentorship and training of senior colleagues.
• Contributes subject matter expertise to develop the research agenda with a clear understanding of the link between scientific project goals and overall long-term business needs.
• Proposes new projects that support the strategic agenda and address gaps in technological capabilities and therapeutic areas.

Requirements

• Master’s degree with 12+ years of relevant experience, or PhD with 8+ years of relevant experience required
• Expert in all aspects of modern medicinal chemistry including, but not limited to SBDD, multi-parameter optimization (MPO) and phenotypic-based drug discovery
• Strong working knowledge of biochemistry, biophysics, ADME, pharmacokinetics, biology, pharmacology, DMPK, and toxicology
• Track record of advancing programs through the stages of drug development from HTS to Pre-clinical Candidate selection
• Demonstrated ability to make strategic recommendations with timely go/no-go decisions at all stages of the drug discovery process
• Proven cross-functional leadership experience as co-project team leader
• Broad experience working with CRO partners
• Track record of innovation and impact on programs documented with co-inventorship on issued patents and authorship of publications in peer-reviewed journals
• Demonstrates excellent verbal and written communication skills
• Proficient in Microsoft Office suite of products (Outlook, Excel, Word, PowerPoint)

Benefits

• medical, dental and vision coverage
• life insurance
• disability insurance
• 401(k) savings plan
• flexible spending accounts
• employee assistance program
• tuition reimbursement program
• group legal
• critical illness
• identity theft protection
• pet insurance
• auto/home insurance
• time off pursuant to sick time policy
• flexible vacation policy
• parental leave policy