Director, Clinical Imaging – Respiratory & Immunology

Role Overview

• Define and lead the cross-program imaging strategy for assigned assets; translate disease biology into actionable imaging endpoints and decision points in the Clinical Development Plan (CDP)
• Serve as the imaging voice on Global Project Teams and Clinical Program Teams, influencing asset strategy and investment
• Lead selection, technical validation, and qualification of imaging endpoints (standard and exploratory), including modality/sequence selection, acquisition/reconstruction parameters, site readiness, and harmonization plans
• Lead all aspects of imaging protocol build, imaging charters, manuals, and risk-based quality management
• Ensure central reads, QC, calibration/phantoms, and site training deliver reproducible, regulator-ready data across multicenter/global trials
• Partner with data science/biometrics to develop data flows (from DICOM to analysis-ready formats), ensure metadata completeness, and apply sophisticated analytics (e.g., radiomics, ML/AI, deep learning, quantitative segmentation) to extract robust signals from large, multimodal datasets
• Champion pre-specification and validation of algorithms and ensure auditability and traceability
• Select and lead imaging CROs, core labs, and image analysis vendors; supervise technical performance and data quality
• Anticipate and address regulatory expectations for imaging endpoints; contribute to interactions, submissions, and responses, including documentation of imaging methods, validation packages, and sensitivity analyses
• Present imaging strategies and readouts to governance and senior partners

Requirements

• At least 5+ years of experience with a Doctoral degree in an imaging-related field (PhD and/or MD) or equivalent sophisticated training
• Strong grounding in clinical imaging modalities, preferably CT and MRI, with strong understanding of acquisition and analysis
• Consistent track record leading imaging endpoints in Phase I–IV trials, including develop, operationalization, and delivery in multicenter settings
• Practical experience in quantitative image analysis and image informatics, including familiarity with DICOM standards, curation, harmonization, and quality control
• Shown ability to analyze and interpret large, multimodal datasets (e.g., imaging + clinical + biomarkers/omics)
• Experience working with statisticians and data scientists to build pre-specified analysis plans and validate algorithms
• Strong cross-functional leadership and influence skills; success working in fast-paced, matrixed environments and driving decisions at asset and program governance
• Excellent written and verbal communication, with the ability to translate sophisticated imaging and analytics concepts to diverse partners.

Benefits

• Short-term incentive bonus opportunity
• Eligibility to participate in equity-based long-term incentive program (salaried roles)
• Retirement contribution (hourly roles)
• Commission payment eligibility (sales roles)
• Qualified retirement program [401(k) plan]
• Paid vacation and holidays
• Paid leaves
• Health benefits including medical, prescription drug, dental, and vision coverage