Vice President, Commercial Strategy, Market Access

Role Overview

• Develop the global pricing strategy, including scenario planning, pricing corridors and gross-to-net assumptions
• Map evidence requirements and gaps to support global payer and HTA decision-making
• Build early payer engagement strategy and plan
• Assess patient support landscape and build launch strategy, inclusive of hub, call center, copay, nurse, and field reimbursement
• Develop US channel strategy for Spyre launch brands
• Determine optimal global launch waves and sequencing to optimize commercial value
• Regularly monitor global policy and pricing landscape changes and assess impact to Spyre portfolio
• Partner with competitive intelligence team to monitor competitor pricing and access dynamics and impact to Spyre
• Partner with CCO and corporate strategy team to refine commercial strategy as Spyre clinical profiles solidify and the competitor landscape shifts
• Influence Phase 3 clinical trial design to ensure alignment with key commercial considerations including pricing, access and demand
• Partner with R&D, Regulatory and Corporate Strategy to refresh target product profile (TPPs)
• Identify and mitigate key commercial risks ahead of Phase 3 investment decisions
• Conduct market research to assess drivers of physician adoption and patient access
• Partner with CCO to build an integrated launch plan, including a detailed commercial launch plan inclusive of commercial resourcing and organizational design
• Identify and partner with external partners who can support commercial launch preparation
• Lead commercial forecasting and scenario modeling, incorporating market access dynamics, competitive landscape, and adoption assumptions
• Partner with Finance team to conduct ROI assessments to aid with portfolio prioritization and launch sequencing strategy
• Generate insights through engagement with payers, KOLs, and advisors
• Partner with Medical team to execute cross-functional KOL engagement plan
• Serve as the commercial lead on Spyre Product Teams
• Ensure alignment between development strategy and commercial success factors
• Contribute to Board and investor materials
• Engage with potential strategics and represent commercial voice in discussions
• Identify and recruit top talent to join commercial organization as the team grows
• Lead, develop and mentor future direct reports
• Other duties as assigned

Requirements

• 12+ years of experience in biotech/pharma across market access, commercial strategy, and/or marketing
• Demonstrated experience developing biotech/pharma commercial and access strategy for assets in Phase 2 and Phase 3 development
• Commercial launch and/or in-line experience, in market access and/or marketing
• Expertise partnering with R&D, Medical and Regulatory to develop value maximizing Phase 3 designs and TPPs
• Deep understanding of global payer dynamics, pricing strategy, and patient access/services
• Experience in commercial forecasting and strategic planning
• Experience building commercial and cross-functionally integrated launch plans
• Track record of successfully influencing across functions
• Excellent communication skills with the proven ability to work effectively in a fast-paced environment.

Benefits

• Opportunity to work in a fast-paced, dynamic environment where you help shape the culture of our young company, contribute broadly to advance meaningful medicines, and learn quickly.
• Market competitive compensation and benefits package, including base salary, performance bonus, equity grant opportunities, health, welfare & retirement benefits.
• Unlimited PTO
• Two, one-week company-wide shutdowns each
• Commitment to provide professional development opportunities.
• Remote working environment with frequent in-person meetings to address complex problems and build relationships.