Co-op: Off-Target Analysis of Gene Editing

Company Overview:

Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.  

Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology & oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.

Fall 2026 Co-op Program: July – December 2026

Co-op Title: Off-Target analysis of Gene Editing

Manager Name: Angela Guo Department: Off-target Biology

 

Assignment Overview

Prime Medicine is seeking a highly motivated co-op to join the Off-target biology team supporting Prime Editing programs. This role will contribute to the safety evaluation of Prime Medicine’s gene editing therapies.

The candidate will work at the interface of cell biology, genome editing, next-generation sequencing (NGS), and Molecular Biology. The coop will work with a scientist to support their off-target analysis of pre-clinical gene editing programs. This will include, cell biology, molecular analysis of Prime Editing components, and next generation sequencing of Prime Editing outcomes. In addition to supporting ongoing work the Co-op will be able to develop a defined project and will work closely with other teams such as Computational Sciences and Screening.

This position offers hands-on experience with cutting-edge gene editing technologies in a fast-paced, collaborative R&D environment focused on developing transformative genetic medicines. We seek a driven team member passionate about advancing human health.

Primary Responsibilities:

· Perform cell transfections and execute gene editing experiments

· Isolate genomic DNA, prepare NGS libraries, and operate Illumina sequencing platforms

· Analyze PE activity in cells including ELISAs and other assays

· Maintain cell lines in culture and become adept at cell handling

· Analyze and interpret sequencing data

· Maintain accurate experimental documentation using an electronic lab notebook system

 

Qualifications:

· Pursuing a B.S. or M.S. in Molecular Biology, Genetics, Bioengineering, or related field

· Hands-on experience with core molecular biology techniques, including PCR and DNA extraction

· Experience with aseptic technique

· Familiarity with genome editing concepts

· Exposure to NGS workflows or sequencing-based assays

· Strong attention to detail, troubleshooting ability, and collaborative mindset

 

Preferred Qualifications:

· Prior mammalian cell culture experience strongly preferred

· Hands-on experience with gene editing and/or NGS techniques

· Experience with laboratory automation and/or data analysis

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity).

Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks.

Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.

U.S. Pay Range$23—$33 USD

Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.