Senior Product Manager, Clinical Genomics

Natera is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. They are seeking a Senior Product Manager to define and drive strategy for core components of the Results, Interpretation, and Reporting (RIR) platform, responsible for shaping scalable, compliant, and cohesive clinical software systems that support complex genomics workflows.

Responsibilities:

• Define and drive multi-year product strategy and roadmap across one or more RIR components, ensuring alignment to clinical quality, regulatory requirements, and commercial scale objectives
• Influence platform-level technical direction in partnership with engineering leadership
• Partner closely with software engineering, bioinformatics, clinical domain experts, quality, regulatory, and other product teams
• Translate business, clinical, and operational needs into clear, actionable product requirements
• Define and evolve end-to-end user workflows, including UI/UX requirements and supporting backend functionality
• Drive cross-team alignment on shared data contracts and workflow standards
• Mentor and raise the bar for product management within the RIR organization
• Own measurable improvements in clinical workflow efficiency, reliability, and operational scalability
• Establish prioritization frameworks that balance regulatory risk, clinical impact, technical scalability, and business outcomes across RIR investments
• Develop and track quantitative metrics related to usability, performance, reliability, and adoption
• Lead delivery teams with clear strategic direction, ensuring requirements reflect long-term platform goals, validation readiness, and system interoperability
• Proactively identify systemic risks, architectural constraints, and workflow inefficiencies that may limit scale or regulatory robustness, and lead cross-functional initiatives to resolve them
• Partner with Quality and Regulatory leadership to shape validation strategy, risk classification, traceability, and audit readiness for RIR software systems
• Create clear, data-driven written proposals and presentations to support stakeholder alignment and decision-making
• Act as a subject matter expert for owned components, supporting design, testing, validation, rollout, and ongoing use

Requirements:

• Bachelor's degree in life sciences, engineering, computer science, statistics, or equivalent experience
• 5+ years of experience in software product management, including ownership of complex, multi-team or platform-level initiatives
• 5+ years experience working on production software in healthcare, clinical genomics, or other regulated lifesciences domains, with demonstrated impact on validation, compliance, and system scalability
• Demonstrated experience influencing engineering architecture and long-term technical investment decisions
• Proven ability to drive alignment across highly matrixed organizations without direct authority
• Track record of independently operating in ambiguous environments and establishing product direction
• Experience with clinical genomics and variant processing and interpretation workflows
• Experience owning user-facing applications, tools, or operational software
• Familiarity working with backend services, APIs, or data-driven systems