Experienced Clinical Project Manager - Inflammation (Sponsor Dedicated/ Remote- US only)

Syneos Health is a leading fully integrated biopharmaceutical solutions organization built to accelerate customer success. They are seeking an Experienced Clinical Project Manager to drive operational execution of a complex Phase 2b inflammation study, managing day-to-day operations and ensuring study milestones are met in a fast-paced environment.

Responsibilities:

• Drive operational execution of a complex Phase 2b inflammation study from study start-up through database lock and closeout
• Independently manage day-to-day study operations with minimal oversight
• Own timelines, deliverables, risks, and issue resolution across multiple workstreams
• Maintain deep operational awareness across all aspects of the trial — this is a role for someone comfortable working 'in the weeds'
• Ensure study milestones stay on track in a fast-paced environment with shifting priorities and competing demands
• Partner cross-functionally to proactively identify risks, remove roadblocks, and implement operational solutions quickly
• Lead vendor management activities and maintain strong oversight of external partners and CROs
• Contribute to RFP development, vendor selection, and ongoing vendor performance management
• Hold vendors accountable to timelines, deliverables, quality expectations, and issue resolution
• Actively manage operational follow-through rather than relying solely on escalation pathways
• Lead cross-functional meetings with clear agendas, action-oriented discussions, and strong follow-up
• Drive accountability across internal teams and external partners
• Build strong collaborative relationships while effectively navigating challenging conversations and competing priorities
• Mentor or support junior team members as needed
• Operate confidently within a matrixed global environment with multiple stakeholders
• Draft, review, and coordinate key study documents including protocols, informed consents, monitoring plans, investigator brochures, and clinical study reports
• Support study budget tracking, forecasting, and operational planning activities
• Review data listings and support interim/final reporting activities
• Train CROs, investigators, study coordinators, and vendors on protocol and study requirements
• Contribute to SOP development, process improvement initiatives, and operational best practices

Requirements:

• 3+ years of clinical project management experience within clinical research
• Experience running clinical trials from start-up through closeout, with a strong understanding of the full clinical trial lifecycle
• Experience supporting complex Phase 2b studies within the inflammation therapeutic area
• Strong CRO/vendor management and oversight experience
• Proven ability to independently drive study execution in fast-paced clinical environments
• Experience managing cross-functional clinical trial activities within matrixed organizations
• Comfortable balancing strategic oversight with hands-on operational execution
• Highly organized with exceptional follow-through and attention to operational detail
• Comfortable working in the weeds while still maintaining a high-level program perspective
• Ability to prioritize effectively and pivot quickly in fast-moving environments
• Strong meeting leadership, communication, and stakeholder management skills
• Confident driving accountability across teams and vendors
• Solutions-oriented mindset with strong initiative and urgency
• High emotional intelligence and ability to navigate high-stakes conversations professionally
• Collaborative, transparent, and team-oriented approach
• Thorough knowledge of FDA and EMA regulations, ICH Guidelines, and GCP requirements
• Strong working knowledge of Microsoft Word, Excel, and PowerPoint
• Ability to interpret and explain protocol requirements, operational processes, and study expectations to teams and stakeholders