Senior Global Project Manager – Immunology, Metabolic, and Oncology (Sponsor-Dedicated) - Home Based in US

Syneos Health is a fully integrated life sciences services organization that supports drug development and commercialization for healthcare innovators. The Senior Global Project Manager / Clinical Trial Leader provides strategic global oversight for Phase II and III clinical trials in Immunology, Metabolic, and Oncology, leading planning, execution, risk management, vendor coordination, closeout, and reporting across multinational teams.

Responsibilities:

• Lead global planning activities and operational feasibility assessments, ensuring timelines and strategies are realistic and globally aligned
• Strengthen cross-functional cohesion by working onsite with colleagues in Statistics, Data Management, Medical Writing, Site Monitoring, Quality, and Regulatory
• Guide country allocation and feasibility processes, helping shape global site strategies with operational insight
• Develop robust global engagement, recruitment, and risk mitigation plans informed by patient, site, and regional feedback
• Lead vendor outsourcing strategy—identification, evaluation, and scope-of-work development—ensuring global operational readiness
• Bring teams together onsite to harmonize trial processes across clinical quality, safety, investigational product management, and financial planning
• Prepare or support responses to regulatory and ethics authorities across regions
• Ensure global teams are trained, aligned, and equipped for execution
• Maintain high-level oversight of worldwide trial operations, ensuring compliance with GCP, SOPs, and diverse regional regulations
• Monitor global patient recruitment, risks, timelines, and budgets, driving issue resolution through clear leadership
• Direct documentation changes, study amendments, and retraining across all regions and functions
• Provide strong oversight of global vendors, central labs, and external partners, ensuring consistent performance
• Serve as the connective tissue across global clinical delivery, fostering open communication and unity of purpose
• Coordinate biomarker, genomic, and sub-study activities for applicable early-phase trials, often requiring cross-regional alignment
• Provide global leadership through data cleaning, database lock, and closeout activities
• Support CTR development and ensure timely global registry disclosure
• Ensure completeness and accuracy of the Trial Master File (TMF) across all participating regions
• Support scientific publications and global communication of study outcomes
• Partner with portfolio leaders to provide operational and scientific insight that shapes global study strategy
• Elevate risks, bottlenecks, and insights to the Evidence Team to drive swift, coordinated solutions
• Lead or contribute to global feasibility assessments that influence trial design, operational models, and regional planning

Requirements:

• Bachelor's degree (4-year undergraduate degree)
• Proven experience providing global leadership across Phase II & III clinical trials
• Therapeutic area experience in Immunology, Metabolic, or Oncology
• Deep understanding of global clinical trial planning, execution, and regulatory landscapes
• Exceptional leadership, communication, and stakeholder management skills across complex, matrixed, multicultural environments
• Ability to lead through influence, anticipate global challenges, and ensure patient-focused outcomes