Associate Director, Pharmacometrics

Role Overview

• Support Crinetics’ translational and early clinical programs by applying mechanistic and quantitative modeling to guide decision-making
• Conduct PBPK and/or QSP modeling directly and/or work with external partners to integrate preclinical, in vitro, biomarker, and early clinical data into predictions
• Help identify quantitative needs at key development milestones and ensure modeling results are translated into clear, actionable insights
• Contribute to scientific review and provide input on population PK, PK/PD, and exposure–response analyses performed internally or through CRO partners
• Inform efficient study designs using mechanistic and empirical modeling to guide dose selection, sampling, and biomarker strategy
• Draft, develop and review program‑level quantitative analysis plans
• Communicate modeling results clearly to project teams, supporting decision-making and governance discussions
• Contribute modeling content to regulatory submissions (e.g., INDs, NDAs, IBs) with increasing independence
• Support departmental objectives, mentor junior staff as appropriate

Requirements

• Pharm.D/Ph.D. or MS in Pharmacokinetics, Pharmaceutical Sciences, Pharmacology, Chemistry, Biochemistry, or related field with a strong understanding of clinical pharmacology principles
• Significant industry experience (Associate Director: MS and 8 years of experience; PhD/PharmD with 5 years of experience) in clinical pharmacology data analysis and interpretation
• Experience with PBPK modeling, QSP modeling, and/or integration of AI/ML into clinical pharmacology decision-making
• Experience interpreting and overseeing population PK and exposure–response analyses
• Familiarity with all stages of clinical drug development, including experience in the preparation of components of the Clinical Pharmacology sections of Regulatory submissions for IND
• and NDA-stage projects
• Experience working in a cross functional team and matrix environment
• Strong written, presentation and verbal communication skills
• Ability to influence business leaders at all levels
• Critical thinker with strong problem-solving skills
• Demonstrated ability to apply quantitative methods to complex problems with growing independence

Benefits

• discretionary annual target bonus
• stock options
• ESPP
• 401k match
• top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance
• 20 days of PTO
• 10 paid holidays
• winter company shutdown