Director – Discovery ADME Project Leader, Bioconjugates

Role Overview

• Keep Safety as a priority
• Develop and implement integrated preclinical ADME strategies aligned with discovery stage, target product profile (TPP), design hypotheses being tested, and regulatory expectations.
• Bring integrated ADME subject matter expertise, driving comprehensive ADME strategy by aligning pharmacokinetics, metabolism, and mechanistic disposition data with early safety signals
• Interpret exposure–toxicity relationships, therapeutic index, and off-target liabilities to proactively de-risk programs and enable data-driven candidate selection decisions
• Integrate ADME, pharmacology, and toxicology to enable translational simulations and modeling to support dose selection, design of PK/PD, efficacy and safety studies.
• Define stage-, modality-, and issue-appropriate screening, decision funnels (in silico, in vitro, in vivo to translational modeling).
• Guide compound design and optimization through data-driven design principles (clearance, permeability, solubility, DDI risk, transporter liabilities)
• Serve as the ADME strategy and science single-point-of-accountability on cross-functional program teams, translating ADME findings into actional design and test hypotheses.
• Collaborate closely with Medicinal Chemistry, DMPK, Toxicology, Pharmacology, and other Discovery Functions to drive high quality candidate selections.
• Contribute to go/no-go decisions using quantitative PK/PD, IVIVE, and mechanistic interpretation.
• Represent ADME in portfolio governance discussions and leadership reviews.
• Implement best practices, assay innovation, and automation where appropriate.
• Drive continuous improvement in data reporting, knowledge management, and decision frameworks.
• Seek and leverage AI and agentic tools where possible to pipeline data, interpret data and share results.
• Maintain inspection-ready documentation and alignment with regulatory expectations.
• Mentor, teach and grow junior scientists and contribute to functional capability building.

Requirements

• PhD in Pharmaceutical Sciences, Pharmacokinetics, Pharmacometrics, Systems Pharmacology, Preclinical or Clinical Pharmacology, Drug Metabolism, Toxicology, Chemical Biology, or related field or Bachelor's with 10+ years experience
• 6+ years of post-graduation industry experience in a drug discovery environment
• Deep subject matter ADME expertise
• A working knowledge of medicinal chemistry and bioconjugates
• Exceptional written and verbal communication skills
• Ability to successfully navigate ambiguity and/or global cross-functional collaborations
• Demonstrated ability to translate complex technical concepts into strategic value for senior leadership and cross-functional partners.

Benefits

• eligibility to participate in a company-sponsored 401(k)
• pension
• vacation benefits
• eligibility for medical, dental, vision and prescription drug benefits
• flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts)
• life insurance and death benefits
• certain time off and leave of absence benefits
• well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)