Principal Scientist – DMPK

Role Overview

• Provide strategic DMPK leadership across a diverse portfolio of projects, shaping translational plans from LO through IND.
• Define and oversee integrated DMPK strategies for both small and large molecule modalities, ensuring alignment with project objectives, target product profiles, and clinical plans.
• Partner with Medicinal Chemistry, Biology, Toxicology, and Clinical teams to co‑create effective translational strategies and risk‑mitigation plans integrating preclinical, in vitro , in silico and emerging clinical data into cohesive translational narratives.
• Take ownership of DMPK and translational inputs to non‑clinical safety assessment, tox species selection, toxicokinetics, and DDI assessment to ensure robust safety margins and risk mitigation strategies.
• Develop and refine human dose projections throughout the preclinical phases, incorporating allometric, mechanistic, and translational approaches.
• Champion the integration of PBPK, PK/PD, and QSP frameworks to support target engagement, FIH dose selection, and scenario planning.
• Contextualise DMPK findings within the broader pharmacology and disease biology to enhance translational relevance and drive data-informed decision-making.
• Mentor and develop senior scientists, fostering a future‑oriented, strategic and innovative culture in DMPK.
• Maintain awareness of emerging technologies and regulatory expectations to keep the organisation at the forefront of translational pharmacology.
• Scan the external landscape and proactively introduce new methodologies (e.g. emerging QSP platforms, novel translational biomarkers, AI/ML enabled modelling) to enhance pipeline productivity.
• Ensure equality and diversity is celebrated and considered as part of all decisions taken.

Requirements

• MSc / Ph.D. in Pharmaceutical Sciences, Pharmacokinetics, or related field with relevant experience in pharmaceutical R&D.
• Proven track record of leading DMPK strategies from LO through IND.
• Demonstrated expertise in PBPK, PKPD modelling, and quantitative pharmacology; experience integrating these into candidate selection and clinical dose projection.
• Strong understanding of translational PK/PD, metabolism, DDI assessment, and toxicokinetics.
• Future-oriented mindset, capable of identifying emerging opportunities in mechanistic modelling and data science.
• Recognized internally and externally as a thought leader in applying DMPK science for translational success.
• Exceptional interpersonal and communication skills; proven ability to influence in interdisciplinary teams.

Benefits

• Health insurance
• Pension scheme
• Flexible working hours
• Professional development opportunities
• Generous benefits package