Key skills
AIPhoenix
About this role
Role Overview
- Provide technical peer review for DMPK and safety in vitro and in vivo study designs. You’ll refine protocols to ensure we generate "gold standard," actionable data.
- Act as the technical lead for our external research partners and CROs.
- Synthesize chemical, pharmacological, and PK data into high-quality summary reports and preclinical dossiers.
- Contribute technical expertise to help the team generate and evolve an appropriate Target Product Profile (TPP), ensuring discovery programmes are aligned to the long-term patient needs.
- Support the Project Leader/Pharmacology team in reviewing AI-generated drug predictions using your DMPK and safety knowledge to identify the candidates most likely to succeed in the clinic.
- Bridge the gap between preclinical, tech, clinical, and commercial teams, providing insights on safety liabilities, drug exposure, and population suitability.
- Proactively seek opportunities to use AI and advanced computational tools to generate and refine DMPK and safety knowledge.
Requirements
- Experience in DMPK within biotech or pharma
- Strong expertise in DMPK modelling (e.g. Phoenix WinNonlin or similar tools)
- Ability to integrate diverse datasets into clear scientific narratives
- Experience using Electronic Lab Notebooks (ELN) and preparing technical reports and preclinical dossiers
- Strong literature and database mining skills, particularly for safety data
- Experience
- or strong interest
- in interpreting non-clinical safety and toxicology data
- Familiarity with evaluating toxicology packages and identifying dose-limiting toxicities
- Experience in oncology and/or neurology is advantageous
Benefits
- Competitive salary, share options, 7% employer pension contributions, life insurance of 4x base salary
- Private medical insurance
- 25 days annual leave (plus bank holidays) with the option to purchase additional days to support a healthy work-life balance and wellbeing support
- Flexible and remote working options
- Home office set-up allowance
- Enhanced family leave policies and flexible working practices
- Personal learning and development budgets
- Regular personal development conversations and career support
- Opportunities to engage with rare disease patient communities and gain insight into patient experiences.
- One paid volunteering day per year to support a cause aligned with our mission